The protein expression of PLAC1/CP1 genes in colorectal carcinoma and its clinical significance
10.3760/cma.j.issn.1007-631X.2010.12.015
- VernacularTitle:PLAC1/CP1蛋白在结直肠癌组织中的表达及其临床意义
- Author:
Fangfang LIU
;
Danhua SHEN
;
Shan WANG
;
Yingjiang YE
;
Chenggang WANG
;
Yanbin ZHANG
;
Qiujing SONG
- Publication Type:Journal Article
- Keywords:
Colorectal neoplasms;
Tumor markers,biological
- From:
Chinese Journal of General Surgery
2010;25(12):985-987
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the protein expression of PLAC1/CP1 ( cancer-placenta 1 ) and its correlation with clinicopathological characteristics in patients of colorectal carcinoma. Methods The expression of PLAC1/CP1 gene was studied by using tissue chip and immunochemistry in 125 cases CRC tissue specimens. Data were analyzed with the x2-test or Fisher's x2 test statistic by SPSS 16. 0 software.Results The protein expression of PLAC1/CP1 gene was 57.6% (72/125) in 125 cases of CRC and 56. 7% (55/97)in 97 primary adenocarcinoma cases. That was 78. 9% (15/19)in poor differentiated colorectal primary adenocarcinoma, those were significantly higher than that of 35.3% (6/17) in well and 55.7% (34/61) in moderately differentiated adenocarcinoma ( P ＜ 0.05 ); PLAC1/CP1 protein expression was significantly higher in stage TNM Ⅲ + Ⅳ 71.2% (37/52) than in stage TNM Ⅰ + Ⅱ 40% (18/45)(P ＜ 0.05 ); PLAC1/CP1 genes expression rate was 69.6% (32/46) in these with lymphoid node metastasis and 45.1% (23/51)in patients without lymphoid node metastasis (P ＜ 0.05 ). The positive expression rate of PLAC1/CP1 increased in colorectal carcinoma with the increasing of the numbers of lymphoid node involved with metastasis( x2 = 13. 353, P = 0.001 ). Conclusions The protein expression of PLAC1/CP1 is associated with tumor differentiation, TNM stage and lymphoid node metastasis.
