Nectin-4 expression in pancreatic cancer and its clinical significance

VernacularTitle:Nectin-4在胰腺癌中的表达及其临床意义
Author: Guangjun SHI ; Lei ZHANG ; Haoqiang CHEN ; Shaohai LUAN ; Jiang YU ; Ping XU
Publication Type:Journal Article
Keywords: Pancreatic neoplasms; Cell adhesion; nectin-4; Immunohistochemistry
From: Chinese Journal of General Surgery 2010;25(12):999-1001
CountryChina
Language:Chinese
Abstract: Objective To investigate the expressions and the clinical significance of nectin-4 in pancreatic carcinoma and the relationship with clinicopathological features. Methods Immunohistocbemical techniques were used to detect nectin-4 expression in pancreatic carcinoma tissues (n = 40) and normal pancreatic tissues (n = 12 ), and the relationship between the expressions and clinicopathological parameters was analyzed. Results The IOD and area of nectin-4 were 2. 43 ± 0.75 and 9. 73 ± 1.86 in pancreatic carcinoma tissues, which were significantly higher than those in the normal pancreatic tissues( P ＜ 0.01 ).The expression of nectin-4 was not correlated with patients demographics ( P ＞ 0.05 ), and the protein expression was correlated with histopathologic grade ( P ＜ 0.01 ) and lymph metastasis ( P ＜ 0.05 ).Conclusions The high expression of nectin-4 in pancreatic carcinoma tissues suggests that its high expression may be correlated with the malignant degree of the carcinoma. nectin-4 can be considered as a reference index of differentiation, metastasis and prognosis in pancreatic carcinoma.