The relationship between suppressor of zeste 12 expression and clinical features of gastric cancer

VernacularTitle:表观沉默蛋白SUZ12与胃癌病理特征及预后的关系
Author: Hui ZHANG ; Yingjiang YE ; Zhirong CUI ; Shan WANG
Publication Type:Journal Article
Keywords: Stomach neoplasms; Gene expression; Pathology,clinical; Prognosis
From: Chinese Journal of General Surgery 2011;26(2):141-143
CountryChina
Language:Chinese
Abstract: Objective To investigate the relationship between the expression of suppressor of zeste 12(SUZ12) and the clinicopathological parameters and prognosis in patients with gastric cancer. Methods SUZ12 protein expression levels in 97 cases of resected gastric cancer were detected by immunohitochemistry method, the relations between SUZ12 expression levels and the survival were estimated by Kaplan-Meier curve. Results The positive rate of SUZ12 expression in gastric cancer tissues was 43%, significantly higher than that (15%)in the adjacent noncancerous tissues( P = 0. 002). SUZ12-positive expression was significantly correlated with tumor differentiation ( P = 0. 018 ), lymph nodes metastasis ( P = 0. 023 ) and TNM staging(P = 0. 014). Gastric cancer patients with SUZ1 2-positive expression had worse prognosis than those with SUZ12-negative expression ( P = 0. 024). Conclusions SUZ12 is overexpressed in tissues of gastric carcinoma, SUZ12 is an independent prognosis factor of patients with gastric carcinoma.