Epstein-Barr virus-associated cutaneous lymphoproliferative disease: two case report
10.3760/cma.j.issn.0412-4030.2011.04.001
- VernacularTitle:EB病毒感染相关的皮肤淋巴增殖性疾病二例
- Author:
Bin QU
;
Hong SHEN
;
Ping WANG
;
Xiaohui ZHENG
;
Xiangdong WANG
;
Tianhong XU
;
Aie XU
- Publication Type:Journal Article
- Keywords:
Lymphoproliferative disorders;
Herpesvirus 4,human
- From:
Chinese Journal of Dermatology
2011;44(4):225-228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To report 2 cases of Epstein-Barr virus-associated cutaneous lymphoproliferative disease (LPD) and to evaluate their relationship with chronic active Epstein-Barr virus (CAEBV) infection.Methods The clinical data on, laboratory examination findings in, treatment and therapeutic response of 2cases of LPD were analyzed. Results Both the patients had chronic intermittent fever, lymphadenopathy, recurrent lesions including papules, papulovesicles, necrosis and variola-like scar in light-exposed and unexposed areas. Pathologically, there was a dermal infiltrate of pleomorphic lymphoid cells with the involvement of perivascular area and some subcutaneous tissue. Immunohistochemical staining showed that most of the infiltrating lymphoid cells were positive for CD8, PCR revealed no TCR-γ gene rearrangement, and in situ hybridization for EBV was positive. The copy of EBV DNA was above the normal range in the peripheral blood from both patients. Clinical status was improved after glucocorticoid treatment. Conclusion The biologic behavior of LPD appears to be a chronic and indolent course and is closely associated with CAEBV.