Detection of serum visfatin and vascular endothelial cadherin (VE-cadberin) in patients with psoriasis vulgaris

VernacularTitle:寻常性银屑病患者血清内脂素和内皮细胞钙黏蛋白的检测
Author: Xu YAN ; Youmin HUANG ; Xueliang MA
Publication Type:Journal Article
From: Chinese Journal of Dermatology 2011;44(4):275-276
CountryChina
Language:Chinese
Abstract: Objective To investigate the roles of serum visfatin and VE-cadherin in the pathogenesis of psoriasis vulgaris and their clinical significance. Methods Enzyme-linked immunosorbent assay (ELISA) was used to detect the serum levels of visfatin and VE-cadherin in 78 patients with psoriasis vulgaris before and after treatment and in 30 normal human controls. The relationship between the two parameters and disease activity was evaluated. Results The serum levels of visfatin and VE-cadherin were significantly higher in untreated patients with psoriasis than in the normal controls (I = 10.53, 10.16, both P< 0.01), and in patients with active psoriasis than in those with stable psoriasis (t = 12.47, 13.11, both P< 0.01). The treatment caused a marked decrease in the serum levels of visfatin and VE-cadherin in patients. The serum level of visfatin was positively associated with the level of VE-cadherin and PASI scores (r = 0.58, 0.64, P < 0.01) in patients with psoriasis. Conclusion Visfatin and VE-cadherin may be used as parameters for evaluating disease activity of psoriasis vulgaris.