Relationship between oxidative stress and the first-phase of glucose-stimulated insulin secretion from pancreatic β cell in individuals with different glucose tolerance
10.3760/cma.j.issn.1000-6699.2011.03.005
- VernacularTitle:不同糖耐量个体氧化应激水平与胰岛β细胞第一时相分泌功能的关系
- Author:
Yongling LI
;
Huacong DENG
;
Gongpu MI
;
Dengyou QIN
;
Jian LONG
;
Zhengping FENG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Intravenous glucose tolerance test;
First-phase of insulin secretion;
Oxidative stress;
A diponectin
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(3):210-212
- CountryChina
- Language:Chinese
-
Abstract:
The relationship between oxidative stress and the first-phase of pancreatic β cell insulin secretion in subjects with different statuses of glucose tolerance was explored. Fasting adiponectin, 8-hydroxydeoxyguanosin ( 8-OHdG), malondialdehyde ( MDA ), superoxide dismutase ( SOD ), insulin area under the curve ( AUC ) from 0 to 10 min, and AIR3-5 were measured. The levels of oxidative stress-related markers were elevated, the activities of superoxide dismutase,adiponectin, and first-phase of insulin secretion were reduced with the disease progression. MDA and 8-OHdG were negatively correlated with adiponectin, homeostasis model assessment β cell function index ( HOMA-β ),AUC ,and AIR3-5. SOD was positively correlated with adiponectin, HOMA-β, AUC, AIR3-5. The plasma 8-OHdG and SOD were independently associated with AIR3-5. Oxidative stress exerts a significant effect on the first phase of pancreatic β cell insulin secretion, which may contribute to the pathogenesis of type 2 diabetes.
