Study on the acetoacetate/β hydroxybutyrate determination in classification of type 1 and type 2 diabetes mellitus
10.3760/cma.j.issn.1000-6699.2011.03.010
- VernacularTitle:乙酰乙酸/β羟丁酸检测用于1型和2型糖尿病分型的探讨
- Author:
Qian LIU
;
Xiaomin XIN
;
Yongguang YU
;
Yingyu JIN
;
Liyan WANG
;
You ZHOU
- Publication Type:Journal Article
- Keywords:
Acetoacetate;
β hydroxybutyrate;
Ketone body;
Diabetes mellitus,classification
- From:
Chinese Journal of Endocrinology and Metabolism
2011;27(3):229-231
- CountryChina
- Language:Chinese
-
Abstract:
The clinical values of acetoacetate ( AcAA ) and β hydroxybutyrate ( βHBA ) determination in classification of type 1 and2 diabetes were explored. 102 normal control subjects,33 cases of type 1 diabetes, and 104cases of type 2 diabetes were enrolled. Serum AcAA, βHBA, fasting plasma glucose ( FPG), C-peptide, and insulin levels were measured. The results showed that serum AcAA, βHBA, total ketone tody (TKB) levels in the diabetic groups were significantly higher than those of the normal group( P＜0. 01 ). AcAA, βHBA, TKB levels in type 1diabetes were higher as compared with those of type 2 diabetes( P＜0.01 ). The AcAA, βHBA, and TKB levels were negatively related with C-peptide and insulin in diabetic patients( P＜0. 01 ). All the type 1 diabetic patient were found to have TKB and lower C-peptide levels. TKB positive and lower C-peptide in type 2 diabetes were found in 47% and 26% respectively. Receiver operating characteristic (ROC) curve suggested that the area under the ROC curve of type 1 and type 2 diabetes was 0.926. The optimal operating point of the total ketone body was 0. 532 mmol/L with higher sensitivity and specificity. Enzymatic determination of acetoacetate and β hydroxybutyrate seems to have important clinical values for classification of type 1 and 2 diabetes.
