Impact of MICA-Ab expression on the prognosis of sensitized renal transplantation recipients
10.3760/cma.j.issn.1001-7097.2011.02.005
- VernacularTitle:致敏肾移植受者主要组织相容性复合物Ⅰ类链相关基因A抗体表达对预后的影响
- Author:
Xiaodong ZHANG
;
Xiaobei LI
;
Yi YANG
;
Jiqing ZHANG
;
Hang LIU
- Publication Type:Journal Article
- Keywords:
Renal transplantation;
Genes,MHC class Ⅰ;
Major histocompatibility complex;
Popular reactive antibody;
Immunoadsorption
- From:
Chinese Journal of Nephrology
2011;27(2):91-95
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of MICA-Ab expression on the prognosis of sensitized renal transplantation recipients.Methods A total of 51 sensitized recipients (PRA more than 20%) in our hospital from August 2007 to April 2010 were enrolled in the study.In these patients,29 cases received protein A immunoadsorption and detection of MICA-Ab was performed before and after protein A immunoadsorption.Other 22 patients received MICA-Ab detection when they were hospitalized.Associations of PRA,HLA-matches,acute rejection,and serum creatinine of postoperative week 1 and week 4 with MICA-Ab were analyzed retrospectively.Results Sixteen recipients (31.4%) had positive MICA-Ab expression but their acute rejection rate was not higher as compared to the patients with negative MICA-Ab expression.Recipients with PRA＞40% showed higher expression level of MICA-Ab than recipients with PRA≤40% (P≤0.05).HLA-match did not show influence on MICA-Ab expression.MICA-Ab positive group had no higher serum creatinine level than negative group in postoperative week 4.MICA-Ab level decreased significantly after protein A immunoadsorption.Conclusions MICA-Ab expression increases in the sensitive recipients but does not influence the prognosis.Protein Aimmunoadsorption can eliminate MICA-Ab effectively in sensitized recipients.
