Effect of continuous venovenous haemodiafiltration on the clearances of various solutes in multiple organ dysfunction syndrome dogs

VernacularTitle:连续性静脉-静脉血液透析滤过对多器官功能障碍综合征犬不同溶质的清除作用
Author: Jihong CHEN ; Che YU ; Jian LIU
Publication Type:Journal Article
Keywords: Hemodiafiltration; Multiple organ failure; Models,animal; Solutes; Clearance rate
From: Chinese Journal of Nephrology 2011;27(2):124-127
CountryChina
Language:Chinese
Abstract: Objective To study the effect of continuous venovenous haemodiafiltration (CVVHDF) on the clearances of various solutes in multiple organ dysfunction syndrome (MODS)dogs.Methods Dogs were subjected to hemorrhagic shock plus resuscitation and endotoxemia to set up MODS model,then they were randomly divided into 2 groups: MODS group (M group)and MODS+CVVHDF group (M+C group).A PRISMA pre-dilution system with AN-69 filter was applied.Solute clearance of nitric oxide(NO),urea nitrogen(UN),creatinine (Cr),interleukin-6 (IL-6),interleukin-10 (IL-10),tumor necrosis factor-α (TNF-α) and endotoxin (LP) was determined with same dialysate and ultrafiltrate volume during CVVHDF.The clearance of various solutes (Kd) was calculated by the concentration of the cleared solutes in effluents (E) based on the formula Kd=(ExQE)/P.Results Clearances of NO,UN,Cr were greater than those of IL-6,IL-10,TNF-α,LP during the treatment of CVVHDF.Conclusion CVVHDF could effectively reduce the levels of various solutes in the development of MODS by convection and absorption.