Exclusive gene mapping on a Chinese familial IgA nephropathy family

VernacularTitle:一个中国汉族家族性IgA肾病家系致病基因的排除性定位
Author: Shumei SHI ; Linghan GAO ; Xuezhi ZHAO ; Aiping ZHANG ; Yaohai DING ; Yanxia WANG ; Guoyin FENG ; Lin HE
Publication Type:Journal Article
Keywords: Glomerulonephritis,IgA; Chromosome mapping; Linkage (genetics); Familial IgA nephropathy
From: Chinese Journal of Nephrology 2011;27(2):77-81
CountryChina
Language:Chinese
Abstract: Objective To initially map the gene responsible for autosomal dominant familial IgA nephropathy of a Chinese family by exclusive the five loci that had been reported with linkage analysis.Methods The genetic pattern of the familial IgA nephropathy was identified and the genomic DNA was extracted from the blood samples collected from the family members.Short tandem repeat (STR) inside the loci that had been reported was selected,such as 2q36,3p23-24,4q26-31,6q22-23,17q12-22,and the data with two-point linkage analysis were performed.Results Autosomal dominant inheritance pattern was demonstrated in phenotypes of the family and there was no linkage relationship in the above five loci of chromosomes because the maximum two-point LOD score was 0.39 at D17S1868.Conclusion Following exclusion of the loci which had been reported,there are other new pathopoiesis loci of FIgAN and it reveals that FIgAN has the genetic heterogeneity according to initial result at the same time.