The study of atorvastatin combined with hydration to prevent contrast-induced nephropathy

VernacularTitle:阿托伐他汀联合水化预防慢性肾功能不全患者造影剂肾病的研究
Author: Xiaobo ZHANG ; Fengying TANG ; Guihua WANG ; Liqin ZHANG ; Weiwei YANG ; Xiaoqi JI
Publication Type:Journal Article
Keywords: Nephrosis; Antilipemic agents
From: Chinese Journal of General Practitioners 2011;10(4):258-259
CountryChina
Language:Chinese
Abstract: One hundred patients with chronic renal failure(CRF) undergoing contrast diagnosis and/or interventional therapy were randomly divided into two groups: patients in hydration alone group( n = 49 )received intravenous infusion of 0.9% sodium chloride 12 h before injection of contrast media till 12 h after examination (hydration), patients in atorvastatin plus hydration group (n = 51 ) received atorvastatin 80mg/d 24 h before examintion for 3 d in addition to hydration.The serum creatinine concentrations were measured before and 48 h after injection of contrast media.In atorvastatin plus hydration group, the incidence rate of contrast-induced nephropathy (CIN) was 8% (4/51), which was significantly lower than that of hydration group (24%,12/49 )(P＜0.05).Short-term and large dose administration of atorvastatin plus hydration can decrease the incidence of CIN in patients with chronic renal failure undergoing contrast diagnosis and/or interventional thrapy.