Plasma levels of N-terminal pro-B-type natriuretic peptide in patients with metabolic syndrome
10.3760/cma.j.issn.1671-7368.2011.02.023
- VernacularTitle:代谢综合征患者血浆氨基末端B型利钠肽前体水平的观察
- Author:
Yuanyuan BAO
;
Xiliang SHANG
;
Linuo ZHOU
;
Renming HU
;
Weiwei ZHANG
;
Wei DING
- Publication Type:Journal Article
- Keywords:
Metabolic syndrome X;
N-Terminal Pro-B-Type Natriuretic peptide
- From:
Chinese Journal of General Practitioners
2011;10(2):128-130
- CountryChina
- Language:Chinese
-
Abstract:
A retrospective analysis was made on clinical data of 230 cases of metabolic syndrome (MS) and 239 cases of non-MS admitted to department of cardiology and endocrinology of Huashan Hospital from July 2005 to August 2009.Multiple linear regression analysis was performed to assess the association between levels of N-terminal pro-B-type natriuretic peptide (NT-proBNP) and potential influencing factors.Covariance analysis was used for group comparison.Multiple linear regression analysis demonstrated that age,body mass index,systolic blood pressure,diastolic blood pressure,insulin resistance index,triglyceride,low density lipoprotein-cholesterol,creatine,left atrial diameter,left ventricular posterior wall dimensions,left ventricular ejection fraction were independent predictors for plasma levels of NT-proBNP in those subjects(P ＜ 0.05).Covariance analysis showed that plasma levels of NT-proBNP in MS group were significantly lower than those in non-MS group ( P ＜ 0.05).Further analysis found that plasma levels of NT-proBNP in MS patients with high triglyceride and body mass index,but normal systolic and diastolic blood pressure,normal fasting plasma glucose were significantly lower than those in non-MS group ( P ＜ 0.05 ).The results indicate that decreased plasma levels of NT-proBNP might be related to lipids disorder and obesity of MS patients.
