Association of microalbuminuria and insulin resistance with acute coronary syndrome
10.3760/cma.j.issn.1671-7368.2011.04.005
- VernacularTitle:尿微量白蛋白及胰岛素抵抗与急性冠状动脉综合征的关系
- Author:
Shaonan LI
;
Guanglian LI
;
Zhen LIU
;
Jiankai HUANG
- Publication Type:Journal Article
- Keywords:
Albuminuria;
Insulin resistance;
Coronary disease
- From:
Chinese Journal of General Practitioners
2011;10(4):237-240
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate relationship of microalbuminuria (MAU) and insulin resistance (IR) to severity of coronary lesions in patients with acute coronary syndrome (ACS), and its predictive value for short-term prognosis in then.Methods In total, 162 ACS patients admitted to the department of cardiology, Guangzhou First People's Hospital, Guangzhou, Guangdong province during January 2008 to June 2009 were selected and divided into three groups according to their urine albumin excretion rate (UAER): 54 cases in normal group with UAER less than 20 μg/min, 62 cases in microalbuminuria group with UAER of (20-200)μg/min, and 46 cases in mass-albuminuria group with UAER more than 200 μg/min.Difference in IR (by homeostasis model assessment, HOMA ) and severity of coronary lesions among the three groups was assessed.Effects of baseline MAU and IR on main adverse cardiac events within the recent six months were observed in ACS patients after percutaneous coronary intervention (PCI).Results IR increased and coronary lesions aggravated as UAER increasing in all the three groups of ACS patients (P＜0.05 or P＜0.01).MAU associated with IR, with a coefficient of correlation of 0.366 (P＜0.01).Results of multivariate logistic regression analysis showed that both MAU and IR were strong independent predictors for main adverse cardiac events in ACS patients within six months after PCI.Conclusions MAU and IR associate with severity of coronary lesions in ACS patients, suggesting certain predictive value for main adverse cardiac events in short-term after PCI.
