Serum heart-type fatty acid-binding protein and platelet activating factor levels in Kawasaki disease and their clinical significance
10.3760/cma.j.issn.1671-7368.2011.04.019
- VernacularTitle:川崎病心型脂肪酸结合蛋白及血小板活化因子的变化及临床意义
- Author:
Ze HONG
;
Xingzhen SUN
- Publication Type:Journal Article
- Keywords:
Mucocutaneous lymph node syndrome;
Fatty acid-binding proteins
- From:
Chinese Journal of General Practitioners
2011;10(4):265-267
- CountryChina
- Language:Chinese
-
Abstract:
Forty six children with Kawasaki disease (observer group) were classified as coronary artery lesions (CAL) subgroup (19 cases) and non-coronary artery lesions (NCAL) subgroup (27 cases)according to echocardiography; 50 healthy children served as control group.Serum heart-type fatty acidbinding protein (h-FABP), platelet activating factor (PAF), cardiac tropnin Ⅰ (cTnI) and creatine kinase isoenzyme MB (CK-MB) levels of all subjects were detected.The results showed that the h-FABP and cTnI levels and positive rate in observer group were higher those in control group (P ＜ 0.05 ), while there were no differences in CK-MB level and positive rate between two groups ( P ＞ 0.05 ).The h-FABP positive rate in observation group was higher than the positive rates of cTnI and CK-MB (P ＜0.05).The PAF level, PLT and polymorphonuclear neutrophil count in observer group were higher than those in control group ( P ＜0.05).The h-FABP and PAF levels in CAL subgroup were higher than those in NCAL subgroup (P ＜0.05).The results suggest that serum h-FABP and PAF can be used as diagnostic indicators for Kawasaki disease complicated with coronary artery lesions.
