Castleman's disease:a report of 45 cases and literature review

VernacularTitle:巨大淋巴结增生症45例临床分析
Author: Dechang DIAO ; Junsheng PENG ; Li ZHOU ; Zuli YANG ; Xiaobin WU ; Jun XIANG ; Honglei CHEN ; Hu SONG
Publication Type:Journal Article
Keywords: Giant lymph node disease; Therapy
From: Chinese Journal of General Practitioners 2011;10(4):271-273
CountryChina
Language:Chinese
Abstract: Clinical features and related information on diagnosis and treatment of 45 cases of Castleman's disease (CD) were retrospectively analyzed.Based on the clinical classification, localized CD (LCD) was found in 26 cases, multicentric CD (MCD) was found in 19 cases.Most cases of LCD presented the symptoms of compression, while MCD had complicated and non-specific clinical manifestations, making the early diagnosis more difficult.All 26 cases with LCD underwent surgery, among which only 2 cases relapsed.Sixteen out of 19 patients with MCD were treated with glucocorticoids or combined chemotherapy, and 14 cases achieved complete or partial remission.The results show that patients with CD have variant manifestation and the diagnosis depend on CT scan or histopathology examination.Most LCD can be cured by complete surgical resection, and MCD can achieve remission by the treatment with glucocorticoids or combined chemotherapy.