Clinical islet transplantation for type 2 diabetes mellitus: 3 cases report
10.3760/cma.j.issn.0254-1785.2011.03.008
- VernacularTitle:成人胰岛移植治疗2型糖尿病三例
- Author:
Yongfeng LIU
;
Ying CHENG
;
Yiman MENG
;
Rui SHI
;
Shurong LIU
;
Guichen LI
;
Gang WU
;
Xuchun CHEN
;
Lei YANG
;
Hong LI
;
Hongying SU
;
Yonghui XIA
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2;
Islets transplantation;
Kidney transplantation
- From:
Chinese Journal of Organ Transplantation
2011;32(3):156-158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the effect of islet transplantation for patients with type 2diabetes mellitus (DM). Methods Since December 2007, 4 cases of islet transplantations were performed on 3 patients with type 2 DM and end-stage renal disease (ESRD). Two patients received simultaneous islet-kidney transplant from single-donor (SIK), and one received 2 consecutive islet transplants 5 months following kidney transplantion (IAK). All recipients given insulin with a dose of percutaneous transhepatic portal catheterization. Anti-CD25 monoclonal antibody was used as induction. For SIK, low-doses of Tacrolimus and sirolimus were used as maintenance immunosuppression protocol. For IAK, the maintenance protocol included cyclosporine and MMF.Insulin dose, the level of blood glucose, C-peptide and the value of HbA1 were observed. Results The first patient of SIKhad normal glucose level 3 days after surgery and became insulin independent within the first month, but insulin was administered gradually and the dose reduced to 1/3. The second patient of SIK died of bleeding and secondary infection of liver puncture site 5 days following operation, the blood glucose level recovered to normal 24 h after operation. The insulin dose of the patient of IAK was reduced to 1/2 after the first transplant. The patient became insulin free after the second operation. The level of fasting and postprandial C-peptide of the surviving recipients increased by 600 pmol/L. The value of HbA1 of the SIK was 6.7 %～7.3 %, while that of the IAK was 5. 5 %～ 5. 9 %. Conclusion Islet transplantation is an effective treatment for patients with type 2 DM.
