The efficacy analysis of domestic pantoprazole in the treatment of non-steroidal anti-inflammatory drugs associated ulcer bleeding
10.3760/cma.j.issn.0254-1432.2011.01.009
- VernacularTitle:国产泮托拉唑治疗非甾体消炎药相关性溃疡出血的疗效分析
- Author:
Xuan HUANG
;
Bin Lü
;
Shuo ZHANG
;
Yi XU
- Publication Type:Journal Article
- Keywords:
Anti-inflammatory agents,non-steroidal;
Peptic ulcer hemorrhage;
Benzimidazoles;
Omeprazole;
Cost-benefit analysis
- From:
Chinese Journal of Digestion
2011;31(1):36-39
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the efficacy, adverse reactions and cost-effectiveness between domestic pantoprazole (Pan Li Su) and imported omeprazole (Losec) in the treatment of non-steroidal anti-inflammatory drugs (NSAID) associated ulcer bleeding.Methods Fifty-eight hospitalized patients with NSAID associated ulcer bleeding were randomly divided into pantoprazole group (n=31)and omeprazole group (n= 27) according to random number table.Pantoprazole group was given 40 mg domestic pantoprazole dissolved 100 ml 0.9% sodium chloride solution intravenously every 12 hours.Omeprazde group was given 40 mg omeprazole dissolved in 100 ml 0.9% sodium chloride solution intravenously every 12 hours.The two groups were both treated for seven days.Finally, the efficacy and adverse effect were observed, and cost-effectiveness was analyzed with pharmacoeconomics.Results The total effective rate of pantoprazole group was 93.5%, omeprazole group was 96.3% .The drugs of the two groups could effectively stop bleeding, the difference was not statistically significant (P= 1.00).The rate of adverse effect was 3.2 % and 7.4 % in the two groups accordingly.The cost-effectiveness ratio (C/E) was 7.76 and 20.73 respectively.Compared with pantoprazole group, the incremental cost-effectiveness ratio of omeprazole group was 454.Conclusions Domesic pantoprazole is an effective, safety and economical medicine for NSAID associated ulcer bleeding.
