The influence of experimental tobacco smoke exposure on brain neurotransmitters in mice
10.3760/cma.j.issn.1674-6554.2011.01.018
- VernacularTitle:环境烟草烟雾暴露对小鼠脑区神经递质表达的影响
- Author:
Aihong YANG
;
Guangwu LI
;
Qingdong HU
- Publication Type:Journal Article
- Keywords:
Environmental tobacco smoke;
Deuto-chronic inhaled;
Neurotransmitters
- From:
Chinese Journal of Behavioral Medicine and Brain Science
2011;20(1):49-50
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanism of the influence on mice brain of environmental tobacco smoke. Methods After the mice were placed into the bench for 8 weeks, the region of the mice brain was localized and the expression of neurotransmitters and neurotransmitters receptors were detected by immunohistochernistry.Results ( 1 ) The expression of GABA in the mice cerebral cortex ( CC ) ( 0. 25 ± 0. 06 ) and the hippocampus (Hip) (0. 19 ± 0. 07 ) were much higher in the ETS-exposed group than that in the control group(P＜ 0. 05 ). (2)The expression of nAChR on CC(0. 31 ±0. 10) was much more in the ETS-exposed group than that in control group(P＜0.05). (3) The expression of NMDAR( Glu receptors) on the CC and striate cortex were much higher in the ETS-exposed group(0.32 ±0. 10,0.38 ±0. 14), NIC-inhaling group(0.31 ±0. 08,0.31 ± 0. 11 ) than that in control group(P＜0. 05 ). Conclusions Long-term ETS-exposed and NiC-exposed environment could change the expression of neurotransmitter and its receptors.
