Effects of different experimental conditions on Kunming and BALB/C mice in forced swimming test

VernacularTitle:不同实验条件对昆明和BALB/C小鼠强迫游泳实验的影响
Author: Hui ZHANG ; Junfeng WANG ; Bo XING ; Yan ZHAO ; Fei LIU ; Jianguo SHI ; Yonghui DANG
Publication Type:Journal Article
Keywords: Mice; Forced swimming test; Immobility; Circadian rhythm; Strains; Gender
From: Chinese Journal of Behavioral Medicine and Brain Science 2011;20(4):306-308
CountryChina
Language:Chinese
Abstract: Objective To investigate the sensitivity and variability factors that were assessed on the forced swimming test (FST) using BALB/C and Kunming mice. Methods The immobility time of FST was compared using Kunming and BALB/C mice in different experimental conditions including circadian rhythm ( day and night) ,gender and water temperature ( 12,22 and 32℃ ) . Results (①) The immobility time of BALB/C during the daytime( ( 142.42 ± 33.58) s) was significantly increased than that at night ( ( 104.89 ± 34.33 ) s). (② The immobility time of Kunming mice( (91.95 ± 40.32) s) was significantly decreased than that of BALB/C mice ( ( 142.42 ± 33.58 ) s). (③)The immobility time under the water temperature of 22 C ( ( 92.24 ± 25.81 ) s) was significant longer than that under the water temperature of 32C ( (60.72 ± 11.11 ) s). Conclusion BALB/C stain,male mice,daytime and water temperature of 22℃ should be chosen in the FST.