The expressions of NRF2 and MRP2 in primary gallbladder carcinoma

VernacularTitle:NRF2与MRP2在原发性胆囊癌中的表达
Author: Mingxin ZHANG ; Hui CAI ; Jiansheng WANG ; Maike YEER ; Jia ZHANG ; Xiaoyi DUAN ; Jingsen SHI
Publication Type:Journal Article
Keywords: Nuclear factor-erythroid 2 p45-related factor 2; Multidrug resistance-associated protein 2; Primary gallbladder carcinoma; Immunohistochemistry
From: Chinese Journal of Hepatobiliary Surgery 2011;17(4):299-301
CountryChina
Language:Chinese
Abstract: ObjectiveTo detect the expressions of Nuclear factor-erythroid 2 p45-related factor 2 (NRF2) and multidrug resistance-associated protein 2 (MRP2), and investigate their significance in primary gallbladder carcinoma. MethodsImmunohistochemistry SP assay and image analysis were used to detect the expressions of NRF2 and MRP2 protein in 59 patients with primary gallbladder carcinoma. ResultsA highly positive expression rates of NRF2 and MRP2 were found (76.3% and 74. 6%, respectively) in primary gallbladder carcinoma. The expressions of NRF2 and MRP2 had a significantly correlation with metastases, Nevin staging, and differentiation (P＜0.05), but there was no statistical association with sex and age. The expression of NRF2 had a positive correlation with MRP2 (r=0. 589,P＜0.05). Conclusion Both NRF2 and MRP2 were overexpressed in primary gallbladder carcinoma and they may play a role in the development of primary gallbladder carcinoma.