The importance of pathological complete ablation on the efficacy of radiofrequency ablation in liver cancer
10.3760/cma.j.issn.1007-8118.2011.03.002
- VernacularTitle:重视病理性完全消融提高肝癌射频消融疗效
- Author:
Wenbing SUN
- Publication Type:Journal Article
- Keywords:
Hepatocellular carcinoma;
Radiofrequency ablation;
Complete ablation;
Residual;
Pathology
- From:
Chinese Journal of Hepatobiliary Surgery
2011;17(3):182-185
- CountryChina
- Language:Chinese
-
Abstract:
Radiofrequency ablation (RFA) has been widely utilized as a potential curative treatment modality for hepatocellular carcinoma (HCC) of early stage. Pathologically, HCC is characterized by the peritumoral microvascular invasion (MVI) and satellite lesion of various scope. Complete ablation of the main tumor, even with a 0.5- 1.0 cm ablative margin, is usually only imaging complete ablation with residual of MVI and satellite lesion, which will grow and affect the therapeutic results. While complete ablation of all the tumor tissue, including the main tumor, peritumoral MVI and satellite lesion, is the pathological complete ablation with no residual of viable tumor cell, which should be the main target of RFA for HCC. This paper summarizes the clinicopathological characteristics of HCC in the perspective of locoregional therapy, the mechanism of RFA to treat HCC, and the common strategies to obtain pathological complete ablaiton.
