Clinicopathological study of subclinical cellular rejection after isolated small bowel transplantation

VernacularTitle:小肠移植后亚临床排斥反应的临床病理研究一例
Author: Bo WU ; Xiaojing AN ; Yuanxin LI ; Yousheng LI ; Hangbo ZHOU ; Rusong ZHANG
Publication Type:Journal Article
Keywords: Small bowel transplantation; Graft rejection; Subclinical; Pathologic processes
From: Chinese Journal of Organ Transplantation 2011;32(4):227-230
CountryChina
Language:Chinese
Abstract: Objective To investigate the clinical presentation, endoscopy and pathological features of subclinical cellular rejection (SCR) of small bowel allotransplantation. Methods Three times of SCR in a patient after isolated small bowel transplantation were studied by endoscopy and microscopy, and the clinical data and literature were reviewed. Results SCR was an unusual type of acute rejection after small bowel transplantation. SCR showed low-grade morphological changes of acute rejection, and may be relived after low-dose steroid or bolus steroid was given. Conclusion The causes of SCR are not clear now. SCR may be the early stage of clinical acute rejections, and may be correlated with unexpected high grade acute rejection, and chronic loss function of graft. The biopsy through ileoscopy is a "golden standard" of diagnosis of SCR in small bowel transplantation.However, the vessel lesions of graft, ileus, and inflammation should be excluded before diagnosis.