Long-term effect of argon plasma coagulation combined with proton pump inhibitor on Barrett esophagus

VernacularTitle:氩离子凝固术联合质子泵抑制剂治疗Barrett食管的长期疗效分析
Author: Hanbing XUE ; Xiaoyu CHEN ; Yunjie GAO ; Yan SONG ; Yunjia ZHAO ; Honghong TAN ; Zhizheng GE
Publication Type:Journal Article
Keywords: Endoscopy; Barrett esophagus; Argon plasma coagulation
From: Chinese Journal of Digestive Endoscopy 2011;28(2):76-79
CountryChina
Language:Chinese
Abstract: Objective To study the long-term effect of argon plasma coagulation (APC) combined with proton pump inhibitor (PPI) on Barrett esophagus (BE). Methods A total of 36 patients, histologically proven as having BE from 2004 to 2007, were enrolled to underwent a therapy of APC plus PPI. The patients were re-examined on endoscopy at 1, 6 and 12 months after first APC and once a year thereafter.Results A total of 48 APC sessions were given to 36 patients with a mean number at 1. 33 per patient. The effective rate of reversal of BE was 100%. The follow-up was accomplished for all patients in 14-51 months with a median of 36months. The total recurrence rate (RR) of BE reached 16. 7% (6/36). The 1-year and 2-year RRs were 2. 8% (1/36) and 11.1% (4/36), respectively. The logistic regression analysis suggested that 2-year and total RRs were related to APC sessions ( P ＜ 0. 01 ). Conclusion The therapy of APC combined with PPI for BE is safe and of long-term effects.