The anti-inflammatory effect of hyperbaric oxygen therapy on acute lung injury induced by lipopolysaccha ride endotoxin
10.3760/cma.j.issn.0254-1424.2011.02.004
- VernacularTitle:高压氧对脂多糖内毒素致急性肺损伤大鼠的抗炎作用
- Author:
Xiaogang PENG
;
Hongmin WANG
;
Jianying LIU
;
Xiangyang YAO
- Publication Type:Journal Article
- Keywords:
Acute lung injury;
Lipopolysaccharide endotoxin;
Hyperbaric oxygen;
Interleukin-8;
Anti-inflammatory effects
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2011;33(2):91-94
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate any anti-inflammatory and curative effect of hyperbaric oxygen (HBO) therapy on mice with acute lung injury (ALI) induced by lipopolysaccaride endotoxin. Methods Fortysix Sprague-Dawley rats, half male and half female, were randomly divided into a normal saline group with 10 rats,an LPS group with 12 rats, and an HBO group with 24 rats. LPS was injected via the tail vein at 5 mg/kg weight to establish the ALI model. The HBO group rats were treated with HBO. Then leucocyte counts, arterial blood gas analysis, interleukin-8 (IL-8) in the blood and lung wet/dry weight (W/D) were compared among the 3 groups at the 3rd and 6th hours. Pathological changes were examined under a light microscope. Results Compared with the LPS group, blood oxygen and W/D were higher in the HBO group, the white blood cell, neutrophil and IL-8 all were lower, and inflammatory cell infiltration was less in lung slides from the HBO group. Conclusions HBO therapy can improve oxygen deficiency and has an anti-inflammatory effect. As a result it might have protective effect against ALI.
