Effects of hyperbaric oxygen on C-reactive protein and tumor necrosis factor-α in patients with moderate and severe traumatic brain injury and its therapeutic efficacy
10.3760/cma.j.issn.0254-1424.2011.02.010
- VernacularTitle:高压氧治疗对中重型颅脑损伤患者血清C反应蛋白和肿瘤坏死因子-α的影响及疗效分析
- Author:
Shuiping WANG
;
Yilong QI
;
Shiquan YANG
;
Xianan SHAO
;
Bensong YU
;
Yiqun WANG
;
Tian XIA
;
Jincheng CHENG
- Publication Type:Journal Article
- Keywords:
Hyperbaric oxygen;
Traumatic brain injury;
C-reactive protein;
Tumor necrosis factor-α;
Glasgow coma scale;
Glasgow outcome scale
- From:
Chinese Journal of Physical Medicine and Rehabilitation
2011;33(2):111-114
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of hyperbaric oxygen (HBO) therapy on C-reactive protein (CRP) and tumor necrosis factor-α (TNF-α) levels in patients with moderate or severe traumatic brain injury (TBI)and to analyze its therapeutic efficacy. Methods One hundred and eight patients with moderate or severe TBI were randomly divided into a control group (54 cases) and an HBO adjunctive therapy group (HBO group, 54 cases).Both groups received essential neurosurgical treatment and conventional drug treatment, and the HBO group was given one session of HBO therapy in addition. Serum CRP and TNF-α were detected, and the scores on the Glasgow coma scale (GCS) were measured before and after treatment. CRP was detected by turbidimetric immunoassay and TNF-α using ELISA. Glasgow outcome scale (GOS) scores were evaluated in a follow-up 6 months after injury. Results Average CRP, TNF-α and GCS measurements showed no statistically significant difference between the groups before treatment. After treatment, CRP and TNF-α were significantly lower and GCS scores significantly better in both groups, but patients in the HBO group were, on average, significantly better than the controls on all three measures.Six months later, GOS evaluation gave a significantly larger number of patients with a better prognosis in the HBO group compared with the controls. Conclusion HBO therapy can significantly decrease serum CRP and TNF-α after severe TBI, thus enhancing therapeutic efficacy.
