Hedgehog signaling pathway and lung cancer
10.3760/cma.j.issn.1006-9801.2011.04.024
- VernacularTitle:Hedgehog信号转导通路与肺癌
- Author:
Xiaoyan BAI
- Publication Type:Journal Article
- Keywords:
Hedgehog signaling pathway;
Lung neoplasms
- From:
Cancer Research and Clinic
2011;23(4):280-283
- CountryChina
- Language:Chinese
-
Abstract:
Hedgehog (Hh) pathway plays a critical role in embryonic development period,which regulates cell proliferation and differentiation,and coordinates the key step of organs' development process such as skin,brain,neural tube,bowels,appendage and lung.In the adult stage,Hh signaling regulates proliferation of stem cells.At this time,Hh signaling is strictly controlled by time and space.In recent years,studies have shown aberrant activation of the Hh pathway is closely related to various types of malignancies,and would be a new therapeutic target of tumor treatment.This paper will review the characteristic of Hh signaling pathway and its research status in lung cancer.
