Progress in the association of high affinity IgE receptor with asthma
10.3760/cma.j.issn.1673-4408.2011.03.024
- VernacularTitle:IgE高亲和力受体与哮喘的研究进展
- Author:
Yi CHU
- Publication Type:Journal Article
- Keywords:
IgE;
FcεRⅠ;
Src tyrosine kinase;
Mast cell;
Childhood asthma
- From:
International Journal of Pediatrics
2011;38(3):280-282
- CountryChina
- Language:Chinese
-
Abstract:
Childhood asthma is one of type Ⅰ allergic diseases,and IgE is indispensable factor in development of asthma.IgE-antigen crosslinking of hish affinity IgE receptor(FcεRⅠ)leads to degranulation of mast cell,leukotriene synthesis and cytokine production.As a re8ult.such changes will bring about inflammation of airway and spasm of airway smooth muscle.Recent researches suggest that Src tyresine kinase play a vital role in their combination.This review discusses the regulation and signaling trannduction of FcεR Ⅰ and the relationship between FcεRⅠ and asthma.
