Immune deviation elicited by retinal S antigen injected into the vitreous cavity
- VernacularTitle:玻璃体腔接种视网膜S抗原诱导的免疫偏离
- Author:
Zhijie LI
;
Guanghua PENG
;
Zheng FENG
;
Chen LI
- Publication Type:Journal Article
- Keywords:
Immunity;
Antigens;
Vitreous body;
Retina;
Interleukin-1
- From:
Chinese Journal of Pathophysiology
1999;15(9):769-772
- CountryChina
- Language:Chinese
-
Abstract:
AIM:To determine whether the vitreous cavity (VC) is capable of supporting the induction of deviant immune response to retinal soluble (S) antigen and to observe the influence of interleukin-1 (IL-1) on the immunologic properties of the VC. METHODS: Retinal S antigen was inoculated into the anterior chamber (AC) and VC in Wistar rats. Seven days after antigen inoculation, the recipient animals were immunized with S antigen and complete Freund's adjuvant. Delayed-type hypersensitivity (DTH) was then assessed by footpad challenge. To alter systemic immune conditions, IL-1 was administrated by intraperitoneal injection. RESULTS: Antigen-specific DTH did not develop in rats in which S antigen was injected into the AC and the VC. In contrast, strong DTH was elicited by S antigen injected into the AC and VC if IL-1 was administrated systemically for 7 consecutive days after the antigen challenge. CONCLUSION: The VC is capable of supporting immune deviation to soluble antigen by actively suppressing antigen-specific DTH. Systemic administration of exogenous IL-1 eliminates the capacity of the VC to support immune deviation inducing by soluble antigen injected locally.
