Progress of the genetic research on asthma
10.3760/cma.j.issn.1673-4408.2011.03.001
- VernacularTitle:哮喘易感基因的研究进展
- Author:
Rui JIN
- Publication Type:Journal Article
- Keywords:
Asthma;
Genetics;
Susceptibility genes
- From:
International Journal of Pediatrics
2011;38(3):203-206
- CountryChina
- Language:Chinese
-
Abstract:
Bronchial asthma is a chronic inflammatory disorder of the airways,caused by multiple genetic and environmental factors.Thtee key methods including candidate gene study,the positional cloning and genomewide association studies.are used for asthma susceptibility gene identification.There are many candidate genes that haye been identified as asthma susceptibility gene, including ADRB2,IL4R,FLG,NPPA,INPP4A,ADAM33, DPP10,OPN3,0RMDL3,PDE4D,CHBLI etc.Replication of genetic associations and demonstration of a functional mechanism for the associated gene variants are needed to COnfirm an asthmasusceptibility gene, this will help us to understand the aetiology of asthma and explore new drugs to treat asthma.
