Progress on the metabolism of antiepileptic drugs by human hepatic CYP3A4 enzymes
10.3760/cma.j.issn.1673-4408.2011.03.022
- VernacularTitle:肝药酶CYP3A4与抗癫(癎)药物的代谢研究进展
- Author:
Junmei ZHANG
- Publication Type:Journal Article
- Keywords:
Liver enzyme;
CYP3A4;
Antiepileptic drugs
- From:
International Journal of Pediatrics
2011;38(3):274-276
- CountryChina
- Language:Chinese
-
Abstract:
Epilepsy is a common disease in nervous system.Most antiepileptic drugs are metabolized by liver enzymes.such as cytochrome P450 enzyme.CYP3A4 iS the most important enzyme in P450 family.involved in the metabolism of about 40%～60% of the drugs use for clinic.It also has a close relationship with the metabolism of antiepileptie drugs.This review summarizes the general characteristic of CYP3A4 and itsrelationship with the metabolism of antiepileptic drugs.
