Identification of differentially expressed proteins in different ovarian tissues by SELDI-TOF MS
10.3760/cma.j.issn.1006-9801.2011.03.007
- VernacularTitle:表面增强激光解吸电离-飞行时间质谱技术对卵巢不同病变组织差异蛋白质的检测
- Author:
Fuhua WANG
;
Shuli SHAO
;
Chunyan WANG
;
Ruihong YANG
;
Yunpeng ZHANG
;
Sutang GUO
- Publication Type:Journal Article
- Keywords:
Ovarial neoplasms;
SELDI-TOF MS;
Proteomics
- From:
Cancer Research and Clinic
2011;23(3):168-170
- CountryChina
- Language:Chinese
-
Abstract:
Objective To search for differentially expressed proteins in normal ovaries,benign,borderline and malignant ovarian tumor protein. Methods The protein from ovarial carcinoma tissue and benign ovary was drawn, and analyzed with SELDI-TOF MS. Results There are some high expression proteins in ovarian cancer tissues: M/Z 15 112.15, 15 296.79, 7560.78, 16 049.39, 7682.06, 7932.30,15 851.32, 4619.68 and 8052.10. Borderline ovarian tumor protein peak were between benign and malignant:M/Z 15 112.15, 15 851.32, 7560.78, 7682.06 and 7932.30. Conclusion There were some differentially expressed proteins in different ovarian tissue. They might lay the molecular basis for the clinical diagnosis and therapy of ovarian cancer.
