Relationship between content of hepatocyte growth factor and nuclear matrix protein 22 in urine and the stage and grade of bladder uroepithelium carcinoma
10.3760/cma.j.issn.1006-9801.2011.03.011
- VernacularTitle:尿肝细胞生长因子和核基质蛋白22含量与膀胱尿路上皮癌分期和分级的关系
- Author:
Ruipeng HOU
;
Tingji ZHANG
;
Guangbo ZHU
;
Xiaobo WANG
- Publication Type:Journal Article
- Keywords:
Urinary bladder neoplasms;
Hepatocyte growth factor;
,Nuclear matrix-associated proteins
- From:
Cancer Research and Clinic
2011;23(3):179-181
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship of the hepatocyte growth factor (HGF) and the nuclear matrix protein 22 (NMP22) in urine and the stage and grade of bladder uroepithelium carcinoma.Methods A total of 48 post-operative patients (males 39, females 9) with bladder cancer enrolled in this study were perfused with THP. The voided urine of all the patients before and 6 months after perfusion were recovered selectively. HGF and NMP22 ELISA kits were used to detect bladder cancer. Results The recurrence rate was 12.5 %. The HGF level had positive correlation with the stage and grade of bladder uroepithelium carcinoma (P ＜0.05). The NMP22 level had positive correlation with the grade of bladder cancer. The sensitivity and specificity of HGF, NMP22 and cytology were 100 % (6/6), 83.3 % (5/6), 66.7 %(4/6) and 61.9 % (26/42), 57.1% (24/42), 97.6 % (41/42), respectively. Conclusion The HGF and NMP22 are both valuable tumor markers in the urine of bladder uroepithelium carcinoma. They have intimate relation with the stage and grade of bladder uroepithelium carcinoma. Hence combined with cytology, they could be selected as the significance level of early screening and diagnosing.
