Genetic polymorphism of GSTM1 to lung cancer patients in north Sichuan of China

VernacularTitle:中国四川北部肺癌患者谷胱苷肽硫转移酶M1基因多态性分析
Author: Daiyuan MA ; Guobo DU ; Bangxian TAN ; Mi LIU ; Yanli ZHAO ; Minghui YANG
Publication Type:Journal Article
Keywords: Lung neoplasms; Polymorphism,genetic; Glutathione transferase
From: Cancer Research and Clinic 2011;23(4):251-253
CountryChina
Language:Chinese
Abstract: Objective To analyze the genetic polymorphism of GSTM1 to lung cancer patients in north Sichuan of China and compare with race from other district.Methods PCR-based technique was used to detect the genotypes of GSTM1 in lung cancer patients.Results In local lung cancer patients,the frequency of homozygous deletions(null genotype) for GSTM1 was 58.4 % (73/125).Among the patients,the frequencys of null genotype for GSTM1 were 62.5 % (20/32) in female,56.9 % (53/93) in male,56.1% (32/57)in patients with squamous cell carcinoma and 54.8 % (17/31) in patients with adenocarcinoma,respectively.The frequency of deletions of GSTM1 in lung cancer patients from north Sichuan of China is slightly exceeding those of Europe and Americas (P ＜0.05) and similar to the domestic result (P ＞0.05).Conclusion The genetic polymorphism of GSTM1 to lung cancer patients in north Sichuan of China dosen' t show distinguished feature for this district and race.