Assays of the minimal residual disease in pediatric acute leukemia
10.3760/cma.j.issn.1673-4408.2011.03.008
- VernacularTitle:儿童急性白血病微小残留病检测方法与评价
- Author:
Li WANG
- Publication Type:Journal Article
- Keywords:
Acute leukemia;
Minimal residual disease;
Flow cytometry;
Polymerase chain reaction
- From:
International Journal of Pediatrics
2011;38(3):229-231
- CountryChina
- Language:Chinese
-
Abstract:
Minimal residual disease(MRD)iS the origin of relapse in leukemia.So it's significant to quantitate MRD in clinical.At present, there are three MRD quantitative assays, such as flow cytometric detection of abnormal immuno-phenotype,polymerase chain reaction(PCR)amplification of antigenreceptor genes and fusion transcripts.Because every measure has its own principle and feature.the clinical applications are different.Selecting suitable assays based on the characteristic of patients can help to quantitate MRD exactly.
