Progress of cyclophosphamide pharmacology and therapy of maligant tumors in children
10.3760/cma.j.issn.1673-4408.2011.03.005
- VernacularTitle:环磷酰胺药理学及其在儿童恶性肿瘤的应用进展
- Author:
Xingjun LI
- Publication Type:Journal Article
- Keywords:
Cyclophosphamide;
Metabolism;
Gene-polymorphism;
Children;
Maligant tumor
- From:
International Journal of Pediatrics
2011;38(3):220-222
- CountryChina
- Language:Chinese
-
Abstract:
Cyclophosphamide is a widely used drug in clinic,which is a non-specific cell cycle nitrogen mustard cytotoxic drug.It is mainly used in the chemotherapy of malignant tumors and autoimmune diseases.Recent studies have found that its differences of metabolism in vivo are connected with the differences of individual genetic level.Some drugs can enhance the anti-tumor effect of cyclophosphamide.There age some progress in the treatment of acute leukemia and lymphadenoma in children.
