Advances in colitis-associated colorectal cancer and dysplasia
10.3760/cma.j.issn.1673-4203.2011.05.019
- VernacularTitle:溃疡性结肠炎相关结直肠癌和非典型增生的研究进展
- Author:
Yanhua ZHOU
;
Shutian ZHANG
- Publication Type:Journal Article
- Keywords:
Ulcerative colitis;
Colorectal neoplasms;
Chemoprevention;
Dysplasia;
Colonoscopic surveillance;
Proctocolectomy
- From:
International Journal of Surgery
2011;38(5):342-345
- CountryChina
- Language:Chinese
-
Abstract:
Patients with long-standing history of ulcerative colitis have an increased risk of developing colitis-associated colorectal cancer.The risk factors include longer duration of colitis,greater anatomic extent of colitis,degree of inflammation of the bowel,family history of colorectal callcer,the presence of primary sclerosing cholangitis.etc.The two kinds of molecular pathogenesis that contribute to colon carcinogenesis are chromosomal instability and microsatellite instability.In order to reduce cancer morbidity,colonescopic surveillance and chemoprevention should be carried out in patients with ulcerative colitis especially in those high risk patients.New endoscopic techniques increase the sensitivity and shed a new light on tumor surveillance.
