Impact of calcium-sensing receptor on hyperparathyroidism
10.3760/cma.j.issn.1673-4203.2011.05.018
- VernacularTitle:钙敏感受体在甲状旁腺功能亢进中的作用
- Author:
Xiaowei WANG
;
Zhiyong CHEN
;
Huagang ZHU
- Publication Type:Journal Article
- Keywords:
Hperparathyroidism;
Calcium-sensing receptor;
Autoantibodies;
Mutation;
Cinacalcet
- From:
International Journal of Surgery
2011;38(5):339-342
- CountryChina
- Language:Chinese
-
Abstract:
Calcium-sensing receptor(CaSR)is expressed in human parathyroid cells and renal tubular epithelial cells mainly.CaSR could control parathyroid hormone(PTH)secretion and the renal tubular's handing of the electrolytes and water.This receptor plays a central role in extracellular calcium homeostasis,and involves in the process of bone remodeling.The change of CaSR function,including anti-CaSR antibodies,CasR gene mutations or any part impairment in CaSR signaling pathway,not only results in the imbalaance of PTH and calcium homeostasis.but also relates to disorders of bone remodeling and renal tubular's mishandling in the electrolytes and water,which contribute to hyperparathyroidism.It makes possible clinical Use of cinacalcet in hyperparathyroidism in theory.
