The relationship between KISS1-GPR54 gene and precocious puberty of children
10.3760/cma.j.issn.1673-4408.2011.03.012
- VernacularTitle:KISS1-GPR54基因与儿童性早熟
- Author:
Lili QIAO
- Publication Type:Journal Article
- Keywords:
KISSI-GPR54;
Precocious puberty;
Gene mutation
- From:
International Journal of Pediatrics
2011;38(3):242-244
- CountryChina
- Language:Chinese
-
Abstract:
Precocious puberty in children begins with the increased pulsatile secretion of the gonadotrophin-releasing hormone(GnRH)from hypothalamic.Recently,KISS1-GPR54 Was found to be a key factor to regulate the secretion of GnRH and the onset of puberty.Kisspeptin interacts with its receptor GPR54.which expressed on the hypothalamic GnRH neurons.and affects GnRH pulsatile release and the onset of puberty.GPR54 gene mutation causes the incidence of GnRH-dependent precocious puberty.
