Recent approach of brain-derived neurotrophic factor and signal transduction pathways in hypoxic ischemic brain damage
10.3760/cma.j.issn.1673-4408.2011.03.020
- VernacularTitle:脑源性神经营养因子及信号传导通路与缺氧缺血性脑损伤
- Author:
Bao JIN
- Publication Type:Journal Article
- Keywords:
Brain-derived neurotrophie factor;
Tyrosine receptor kinase B;
Signal transduction pathways;
Hypoxic ischemic brain damage;
Child
- From:
International Journal of Pediatrics
2011;38(3):267-270
- CountryChina
- Language:Chinese
-
Abstract:
Brain-derived neurotrophic factor(BDNF)belongs to the neurotrophin family and abundantly expressed in the nervous system.It plays an essential role in the survival,development,function,morphogenesis and plasticity of neurons by binding to the tyresine receptor kinase B(TrkB)and subsequent downstream activation of several signal transduction pathways in the nervous system. The PI3K/Akt and the MAPK/ERK DathWays ale two major intracellular signaling network activated by BDNF involved in survival of neurons.Becently.it is investigated that BDNF and TrkB are involved in the pathophysiology of hypoxic ischemic brain damage (HIBD)and in the mechanism of action of therapeutic agents.Therefore we image changing the internal or external condIitions can increase the expression of BDNF,thsu reduce the nervous system damage of HIBD.
