Effect of anti-digoxin antiserum on endogenous digitalis-like factor and membrane ATPase activity in hypoxic injury myocardium
- VernacularTitle:地高辛抗血清对缺氧损伤心肌组织内源性地黄样因子和心肌细胞膜ATP酶活性的影响
- Author:
Yongsheng KE
;
Hao YANG
;
Ting YANG
;
Guanghua CHENG
;
Youxia WANG
- Publication Type:Journal Article
- Keywords:
myocardium;
hypoxic injury;
endogenous digitalis-like factor;
Na+-K+-ATPase;
Ca2+-ATPase;
anti-digoxin antiserum
- From:
Chinese Journal of Clinical Pharmacology and Therapeutics
2000;5(1):10-13
- CountryChina
- Language:Chinese
-
Abstract:
To evaluate the protective effect of anti-digoxin antiserum on hypoxic injury myocardium and its mechanism.Methods It was observed that different concentration anti-digoxin antiserum effect on endogenous digitalis-like factor and cell membrane ATPase activity in hypoxic myocardium model.Results The level of endogenous digitalis-like factor was remarkably higher,cell membrane ATPase activity were remarkably lower in hypoxic group than those of normal group;anti-digoxin antiserum can resume membrane ATPase activity.Conclusion Rise of endogenous digitalis-like factor was basic of molecular biology of myocardial damage during myocardial hypoxia.Anti-digoxin antiserum has lightened myocardial injury and has protective effect on hypoxic myocardium by against effect of endogenous digitalis-like factor.
