Progress of relationship between HOXA7 gene and leukemia
10.3760/cma.j.issn.1673-4408.2011.03.015
- VernacularTitle:HOXA7基因与白血病
- Author:
Wenwen FAN
- Publication Type:Journal Article
- Keywords:
HOXA7;
Leukemia;
Homebox gene
- From:
International Journal of Pediatrics
2011;38(3):251-254
- CountryChina
- Language:Chinese
-
Abstract:
As a member of homeobox gene family,HOXA7 is a main gene to control hematopoietie cell proliferation and differentiation.The expression and function of HOXA7 in leukemia ale regulated by many upstream elements.and affected by synergism molecules and other homeobox genes. It can induce leukemia through acting on downstream target genes.HOXA7 affects the clinical manifestation of leukemia and overexpression is closely associated with poor therapeutic reaction and prognosis.
