Effect of mild hypothermia on fibrinolysis system in ischemic stroke
10.3760/cma.j.issn.1673-4165.2011.04.014
- VernacularTitle:亚低温治疗对缺血性卒中纤溶系统的影响
- Author:
Yujie LAI
;
Dan YU
- Publication Type:Journal Article
- Keywords:
Hypothermia,induced;
Stroke;
Brain ischemia;
Fibrinolysis;
Tissue plasminogen activator;
Plasminogen activator inhibitor 1
- From:
International Journal of Cerebrovascular Diseases
2011;19(4):307-309
- CountryChina
- Language:Chinese
-
Abstract:
The imbalance in the fibrinolytic system participates in the pathophysic-logical processes of ischemic stroke. Most researchers consider that the fibrinolytic activity decreases in patients with ischemic stroke, while others believe that it increases. Mild hypothermia is a therapeutic approach with great potential and plays the neuroprotective effect through a variety of mechanisms. Animal experiments have demonstrated that the treatment with mild hypothermia may increase the plasma fibrinolytic activity and decrease the expression of local plasminogen activator in ischemic area. Howere, the related clinical research studies are few, and most of them are limited in the safty and collaborative research of mild hypothermia combined with other treatment therapies.
