Effects of high-frequency jet ventilation on oxidative stress in patients during one lung ventilation
10.3760/cma.j.issn.1673-4904.2011.15.008
- VernacularTitle:高频喷射通气对单肺通气患者氧化应激反应的影响
- Author:
Zhiqing YIN
;
Zhongyou HE
;
Zhenfei YUAN
;
Beibei WANG
;
Ruifeng QIAN
;
Yanhong WANG
- Publication Type:Journal Article
- Keywords:
High-frequency jet ventilation;
One-lung ventilation;
Oxidative stress
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(15):18-20
- CountryChina
- Language:Chinese
-
Abstract:
Objective To determine the effects of high-frequency jet ventilation (HFJV) on oxidative stress in patients during one-lung ventilation (OLV). Methods Forty-five patients undergoing elective radical esophageal cancer resection were divided into three groups with 15 cases each by random digits table: two lung ventilation group ( group A), OLV group (group B), HFJV- OLV group ( group C, working pressure 1 kg/cm2 and frequency 100 times/min). Venous blood samples were taken before induction (T0),at30min (T1),90min (T2),150min (T3) after OLV and the end of operation (T4) for measuring serum superoxide dismutase(SOD),malondialdehyde (MDA) and nitric oxide (NO). Results SOD was lower at T2-T4 in group B[(47 ± 10), (37 ±9), (41 ±7) kU/L] and group C[(58 ± 12), (51 ± 11), (49 ± 9) kU/L] than those in group A [(78 ±8), (75 ±7), (79 ±6) kU/L](P＜ 0.05),and MDA and NO were lower at T1-T4 in group B and group C than that in group A(P＜ 0.05). SOD was higher at T3 in group C than that in group B (P ＜ 0.05), MDA at T1-T4 and NO at T2-T4 were lower in group C than those in group B (P ＜ 0.05). Conclusion HFJV can effectively decrease oxidative stress in patients during OLV.
