Effects of short term insulin pump therapy on endothelia-dependant flow-mediated dilation in type 2 diabetes mellitus patients
10.3760/cma.j.issn.1673-4904.2011.13.004
- VernacularTitle:短期胰岛素泵强化治疗对2型糖尿病患者内皮依赖性血管舒张功能的影响
- Author:
Pengfei YANG
;
Xiaofeng LV
;
Yu GAO
;
Xinxin NIU
- Publication Type:Journal Article
- Keywords:
Insulin infusion systems;
Diabetes mellitus,type 2;
Vasodilation
- From:
Chinese Journal of Postgraduates of Medicine
2011;34(13):11-14
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effects of short term insulin pump intensive therapy on flow-mediated dilation (FMD) in type 2 diabetes mellitus (T2DM) patients with and without vascular complications. Methods Seventy-six patients with T2DM (T2DM group) were divided into 2 subgroups: T2DM1 subgroup (28 patients with vascular complications) and T2DM2 subgroup (48 patients without vascular complications). Meanwhile, 30 healthy cases were selected as NC group. All research subjects accepted high-frequency ultrasound detection on brachial artery for FMD. After insulin pump intensive therapy,FMD in T2DM group was reexamined, fasting insulin was detected and HOMA-IR was calculated. Results Compared with that in NC group, FMD in T2DM group was significantly lower(P＜ 0.01). However, glycosylated hemoglobin (HbA1c ), fasting plasma glucose (FPG ),H0MA-IR and blood fat were significantly higher (P＜0.01 or ＜0.05). Correlation analysis showed that FMD had negative correlation with HbA1c, FPG, HOMA-IR, triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C)(P＜0.01),and had positive correlation with high-density lipoprotein cholesterol (HDL-C). After 2 weeks of insulin pump therapy, the improvement of FMD between the two groups was different. FMD in T2DM1 subgroup increased from (4.25 ± 1.96)% to (4.96 ± 1.36)%(P＞0.05), and FMD in T2DM2 subgroup increased from (4.02 ± 2.35)% to (7.56 ± 2.34)%(P＜ 0.01). Conclusion Insulin pump intensive therapy can evidently improve FMD in T2DM patients without vascular complications.
