Expression in breast cancer and its clinical significance
10.3760/cma.j.issn.1008-6706.2011.10.010
- VernacularTitle:核因子-κB在乳腺癌组织中的表达及意义
- Author:
Xuhui WU
;
Xia QIU
- Publication Type:Journal Article
- Keywords:
Breast neoplasms;
Nuclear factor-κB;
Immunohistochemistry
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(10):1317-1318
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore NF-κB(P65)expression in breast cancer and its clinical significance.Methods Immunohistochemical staining was used to examine the expression of NF-κB(P65)and its relationship with related elinicopathological factors were analyzed in eighty-seven IDC(invasive ductal cancinoma).Results NFκB(P65)expression was significantly correlated with lower tumor grading,maxilary lymph node metastasis,later TNM styng and HER-2 positive(all P＜0.05),but not with tumor size,age of the patient and the state of ER、PR.Conclusion NF-κB(P65)should be risk factors of poor prognosis in IDC.
