The myocardial protective effect of ischemic post-conditioning on infants with total repair for tetralogy of fallot
10.3760/cma.j.issn.1008-6706.2011.10.009
- VernacularTitle:缺血后处理对婴幼儿法洛四联症根治术中心肌的保护作用
- Author:
Zhimin ZHONG
;
Chao LIU
;
Huanqing ZHONG
;
Cuixian XIE
;
Lian HU
- Publication Type:Journal Article
- Keywords:
Tetralogy of Fallot;
Cardiac surgical procedures
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(10):1314-1316
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the myocardial protective effect of isehemic post-conditioning in total repair for tetralogy of fallot,in order to improve short-term prognosis of infant patients.Methods 64 cases of TOF infant patients were randomly divided into two groups,32 cases in the control group:conventional surgery without ischemic post-conditioning,and other 32 cases in the experimental group:given three cycles of ischemic post-conditioning.Then the clinical indieators:cardiopulmonary bypass time,aortic cross-clamping time,automatic re-jump rate,the latter parallel to the off-line time,the off-line blood pressure,the offline dopamine usage,extubation time,ICU stay time,postoperative complications,and the testing laboratory indicators:the cTnI and CK-MB levels in plasma after anesthesia induction,10min after aortic cross-clamping,10min after aortic opening,ICU1h,1d after surgery,and 2d after surgery were observed.Results Two patients were died and,mortality rate was 3.1%.The remaining patients were discharged from hospital.Laboratory indicators of the control group and the experimental group had significant differences (all P＜0.05),while the clinical indicators of the two groups had no significant differences(all P＞0.05).But for the sub-group which the aortic cross-clamping time were more than 60min,the clinical indicators were significantly different(all P＜0.05).Conclusion Ischemic post-conditioning could enhance myocardial protection in total repair for tetralogy,of fallot.for the cases aortic cross-clamping time was more than 60min,their clinical meanings were more obvious.
