The relationship between plasma ghrelin levels and glucose and lipid metabolisms of child and adolescent obesity
10.3760/cma.j.issn.1008-6706.2011.10.005
- VernacularTitle:肥胖患儿血糖、血脂与血浆生长激素释放多肽水平的关系
- Author:
Qin ZHANG
;
Wei CHEN
;
Xiu ZHAO
;
Jianxiang LIAO
;
Yongbai LI
;
Chengrong LI
- Publication Type:Journal Article
- Keywords:
Adolescent;
Obesity;
Ghrelin
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(10):1306-1307
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between plasma ghrelin levels and glucose and lipid metabolisms of child and adolescent obesity.Methods 30 cases of obesity and 30 healthy normal weisht children and adolescents with same age and gender were selected.Plasma ghrelin level,serum insulin(INS),C-peptide(CPE),fasting blood glucose(FBG),total cholesterol(TC),triglyceride(TG),high-density lipoproteins(HDL),low-density lipoproteins(LDL)were measured.Results For the obesity group:Plasma ghrelin level significantly decreased [(15.49±1.98)vs(19.47 ±1.50)μg/L]compared with control(P＜0.05);BMI,waistline,FBG,INS were very significantly increased(28.19±3.83)vs(21.07±1.53)kg/m2;(88.60±6.13)vs(78.52 ±4.40)cm;(5.23±0.49)vs(4.59 ±0.63)mmol/L;(22.32 ±3.50)vs(16.98±2.50)μIU/ml,respectively compared with control(all P＜0.01);TC was significantly increased(5.87±0.88)vs(4.05±0.76)nmol/L compared with control(P＜0.05).For the plasma ghrelin level of obesity:The relationship between plasma ghrelin level and body weight,BMI,waistline,INS,TC was obviously negative(r=-0.385,-0.466,-0.336,-0.387,-0.373,respectively,all P＜0.01);The relationship between plasma ghrelin level and FBG was obviously negative(r=-0.324,P＜0.05);No relationship between plasma ghrelin level and age,body height,CPE,TG,HDLC,LDLC.Conclusion Plasma ghrelin level of children and adolescent obesity was obviously decreased,and was strongly related with disordem of glucose and lipid metabolisms.
