Clinical observation of bisoprolol combined with methimazole in trealment of hyperthyroidism

VernacularTitle:比索洛尔联合甲巯咪唑治疗甲状腺功能亢进症的临床观察
Author: Weiping YANG
Publication Type:Journal Article
Keywords: Hyperthyroidism; Bisoprolol; Methimazole; Curative effect
From: Chinese Journal of Primary Medicine and Pharmacy 2011;18(9):1196-1198
CountryChina
Language:Chinese
Abstract: Objective To explore the clinical effect and safety of bisoprolol combined with methimazole in treatment of hyperthyroidism.Methods 100 cases with hyperthyroidism were randomly divided into control group (methimazole treatment)50 case.$and treatment group(bisoprolol combined with methimazole treatment)50 cases.The therapeutic effect,serum levels of FT3,FT4 and s-TSH were observed.Results The total effective rate in treatment group 92.0% was significantly higher than 78.0%in control group(χ2=3.798,P＜0.05);The contents of TT3,TT4,FT3,FT4 after treatment were lower than before treatment(t=2.245,2.315,2.411,all P＜0.05);The contents of S-TSH was higher than before treatment(t=2.335,P＜0.05);Hyperthyroidism exponential integral in treatment group decreased significantly than the control group(t=2.312,P＜0.05).Conclusion The bisoprolol combined with methimazole treatment could efficiently improve clinical symptoms,raise therapeutic effect in patients with hyperthyroidism.