Effect of leukotriene receptor antagonist on the airway inflammation in bronchiolitis after respiratory syncytial virus infection
10.3760/cma.j.issn.1008-6706.2011.09.004
- VernacularTitle:白三烯受体拮抗剂对毛细支气管炎后气道炎症的影响
- Author:
Jianjiang CHEN
;
Jinjun GUO
;
Huimin LI
;
Wei LI
;
Shaoxian WANG
;
Xueling WAN
- Publication Type:Journal Article
- Keywords:
Leukotriene receptor antagonist;
Capillary bronchiolitis;
Eosinophil cationic protein;
Intefleukin-12;
Interleukin-13;
Leukotriene
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(9):1161-1163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the effect of leukotriene receptor antagonist on the airway inflammation in bronchiolitis after respiratory syncytial virus(RSV)infection and the prevention of post-bronchiolitis asthma by studying the changes of serum concentration of inflammatory cellular factors including ECP,IL-12,IL-13 and LTE4.Methods 156 children with mild and moderate RSV bronchiolitis were recruited in the study and they were randomly divided into three groups after alleviation of asthmatic symptoms:the intervention group with montelukast sodium tablets oral;hormone intervention group with Budesonide suspension spray;control group.Blood samples were collected on the first day on admission,before treatment,3 months after medication.Serum concentrations of ECP,IL-12,IL-13 and LTE4 were measured by ELISA.Clinical and telephone follow up was done for one year.Results Compared to control group,the ECP,IL-13 and LTE4 levels of 156 RSV bronchiolitis in acute phase and recovery phase were signifieantly increased,while the IL-12 level was significantly decreased.The ECP,IL-13levels of singulair intervention group and the hormone intervention group were decreased after intervention,and the IL-12 level rise to normal;the LTE4 level of singulair intervention group and the hormone intervention group decreased significantly than before intervention,singulair intervention group recovered to normal levels(t=1.0866,P＞0.05),but hormone treatment group did not recover to normal levels(t=3.4355,P＜0.01).Singulair intervention group had lower recurrence of asthma(χ2=7.8156,P＜0.01).Conclusion The leukotriene receptorantagonists could regulate the imbalance of Th1/Th2,reduce the release of LTE4 and the activation of eosinophils,alleviate airway inflammation and airway hyperreactivity,reduce wheezing,and it play a role in the prevention of asthma.
