Clinical research on correlation between CT-1 and cardiac function in patients with diabetic cardiopathy
10.3760/cma.j.issn.1008-6706.2011.09.002
- VernacularTitle:糖尿病心脏病患者血浆心肌营养素-1水平与心功能的关系
- Author:
Chujia LIN
;
Shaoda LIN
;
Shaowei HUANG
;
Guangrui SU
- Publication Type:Journal Article
- Keywords:
Diabetic;
Cardiopathy;
Cardiotrophin-1;
Cardiac function
- From:
Chinese Journal of Primary Medicine and Pharmacy
2011;18(9):1156-1158
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the eorrelation between the plasma cardiotrophin-1(CT-1)level and cardiac function of patients with diabetic cardiopathy.Methods Using the Biotin-StreptAvidin-enzyme-linked immunosorbent assay(BSA-ELISA),the level of plasma CT-1 jn 35 normal controls,40 patients with type 2 diabetes and 60 patients with diabetic cardiopathy was measured.The relation to heart function was observed.Results The difference of plasma CT-1 level in the three groups was significant(all P＜0.05).The level of plasma CT-1 in diabetic cardiopathy group was apparently higher than that of type 2 diabetes group and normal controls(all P＜0.01);The level in type 2 diabetes group was significantly higher than that of normal controls(P＜0.01).The level of plasma CT-1 elevated with the worsening of heart failure(NYHA classification).The level of plasma CT-1 was correlated with EF(r=0.669,P＜0.01);LAD(r=0.528,P＜0.01);PVE(r=0.502,P＜0.01);CK-MB(r=0.312,P＜0.01);TG(r=0.187,P＜0.05);DBP(r=0.158,P＜0.05)o Stepwise regression analysis revealed that EF and LAD were the most significant agents affecting the plasma CT-1.Conclusion The plasma CT-1 level could reflect the state of cardiac function of diabetic cardiopathy patient,it could help to diagnose diabetic cardiopathy earlier.
